what is BOTOX ® Cosmetic?
  • BOTOX® Cosmetic is the only approved treatment to temporarily improve the appearance of both moderate to severe frown lines between the brows and crow’s feet lines in adults.

  • A well-studied treatment
    BOTOX® Cosmetic is one of the most extensively studied medical aesthetic treatments and is approved for cosmetic use in 78 countries.* BOTOX® Cosmetic has a record of experience that aesthetic specialists know and trust. And, the safety and efficacy of BOTOX® Cosmetic have been evaluated in both Allergan sponsored clinical trials as well as in 417 peer-reviewed articles in scientific and medical journals.

    *VISTABEL® outside of North America.

  • Derived from sources that exist in nature
    BOTOX® Cosmetic contains tiny amounts of a highly purified botulinum toxin protein refined from the bacterium, Clostridium botulinum. Formulations, potency, and approved doses vary among botulinum toxin products, which means that one product cannot take the place of another. Those are a few reasons why there is no such thing as a “generic” form of BOTOX® Cosmetic. There have been no studies to support that other products are Unit-to-Unit equivalent to BOTOX® Cosmetic.

  • A treatment experienced by millions of people
    Approximately 10.9 million vials of BOTOX® Cosmetic have been sold in the United States since 2002, and millions of people have already made BOTOX® Cosmetic a part of what they do for themselves. Today, BOTOX® Cosmetic is the #1 selling product of its kind in the world.

    Data collected through June 2014.

Actual BOTOX(R) Cosmetic (onabotulinumtoxinA) patient after treatment.
how does BOTOX ® Cosmetic work?
  • BOTOX® Cosmetic targets one of the underlying causes of frown lines and crow’s feet—the repeated muscle contractions from frowning and squinting over the years. Your specialist will inject these muscles with BOTOX® Cosmetic to temporarily reduce muscle activity. You will begin to notice a visible smoothing of your crow’s feet lines and frown lines between your brows.

  • Wrinkles result from a combination of many factors. It’s not just about cellular changes that can occur over time, reduction of collagen, or damage caused by free radicals in the sun and the environment. When you frown or concentrate, the muscles between your brows contract, causing your skin to furrow and fold. And when you squint, the muscles around your eyes contract and cause crow’s feet.

    BOTOX® Cosmetic works beneath the skin’s surface and targets the underlying muscle activity that causes frown lines and crow’s feet.

  • For the crow’s feet area, your specialist will inject 3 areas of the orbicularis oculi, the muscle that frames the side of the eye. This will be repeated on the orbicularis oculi muscle on the other eye.

    Injecting BOTOX® Cosmetic into the muscles that cause crow’s feet lines temporarily reduces the activity of those muscles. The result is a reduction in the appearance of those lines.

  • For the frown lines area, your specialist will administer 5 injections into muscles in your forehead—1 in the procerus muscle and 4 in the corrugator muscles.

    Injecting BOTOX® Cosmetic into the muscles that cause frown lines temporarily reduces the activity of those muscles. The result is a reduction in the appearance of those lines.

Actual BOTOX(R) Cosmetic (onabotulinumtoxinA) patients after treatment. Crow's feet injection points Frown lines injection points
What should I expect with treatment?
  • Real, noticeable results
    You may begin to notice results within 24 to 48 hours for moderate to severe frown lines, with results lasting up to 4 months.

  • Some patients report that being injected with BOTOX® Cosmetic feels like a pinch
    Your specialist may use ice to numb the treatment area. If you are concerned about discomfort, your specialist may apply a topical numbing cream before administering your treatment.

  • The actual injection process takes about 10 minutes
    Your specialist will discuss your treatment goals and perform a facial analysis to determine the appropriate treatment areas for you.

  • You’ll look like yourself—only with less noticeable frown lines and crow’s feet
    BOTOX® Cosmetic is a technique-sensitive treatment. You should not lose the ability to show expression when you are treated by someone who is licensed, trained, and a medical expert in facial anatomy.

  • Return to your daily routine
    Treatment requires minimal downtime or recovery; it’s often called a lunchtime procedure. You’ll be able to go about your normal routine immediately after you leave your specialist’s office.

  • Cost considerations
    Your cost not only includes the price of the product, but more importantly, the skill and expertise of the specialist or healthcare professional who is administering your treatment.
    BOTOX® Cosmetic is a technique-sensitive treatment—look for someone who is licensed and trained and has experience treating patients with BOTOX® Cosmetic.

    Be wary of discount products or “cheap” BOTOX® Cosmetic—if it sounds too good to be true, it probably is.

    It is more important to find an experienced specialist who will take the time to understand your treatment goals and develop a treatment plan that is right for you.

After (Day 7)

Actual patient. Results may vary.

Photos taken at maximum frown and/or full smile before and after treatment with BOTOX® Cosmetic at day 7. In two clinical studies for moderate to severe crow’s feet, 26.1% and 20.3% of people had ≥ 2-grade improvement at day 30. In one of these studies, 67.9% of people had mild or no crow’s feet at day 30 after treatment. In clinical studies for moderate to severe frown lines, physicians assessed 80% of people had significant improvement at day 30.

Side effects associated with the injection include localized pain, infection, inflammation, tenderness, swelling, redness, and/or bleeding/bruising.

steps you can take
Simple steps to make sure that you are receiving real BOTOX® Cosmetic.
  • Step 1
    See a reputable provider who purchases BOTOX® Cosmetic directly from Allergan or a distributor authorized by Allergan.

    Physicians who purchase BOTOX® Cosmetic from Allergan are listed in the Find a Doctor directory on this website.

  • Step 2
    Ask to see the vial of BOTOX® Cosmetic that the specialist will use during your treatment. The vial will have the BOTOX® Cosmetic logo and also have a holographic image that says Allergan.

  • Guaranteed for quality
    When a US specialist purchases BOTOX® Cosmetic through Allergan or a distributor authorized by Allergan, it is guaranteed for quality. BOTOX® Cosmetic is a biologic product and follows strict manufacturing, storage, and transportation procedures that prevent it from being compromised.

Authentic BOTOX(R) Cosmetic (onabotulinumtoxinA) vials

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  • Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months
  • Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing

BOTOX® Cosmetic dosing units are not the same as, or comparable to, any other botulinum toxin product.

There has not been a confirmed serious case of spread of toxin effect when BOTOX® Cosmetic has been used at the recommended dose to treat frown lines, crow’s feet lines, or both at the same time.

BOTOX® Cosmetic may cause loss of strength or general muscle weakness, vision problems, or dizziness within hours to weeks of taking BOTOX® Cosmetic. If this happens, do not drive a car, operate machinery, or do other dangerous activities.

Serious and/or immediate allergic reactions have been reported. They include: itching, rash, red itchy welts, wheezing, asthma symptoms, or dizziness or feeling faint. Get medical help right away if you are wheezing or have asthma symptoms, or if you become dizzy or faint.

Do not take BOTOX® Cosmetic if you: are allergic to any of the ingredients in BOTOX® Cosmetic (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as Myobloc® (rimabotulinumtoxinB), Dysport® (abobotulinumtoxinA), or Xeomin® (incobotulinumtoxinA); have a skin infection at the planned injection site.

Tell your doctor about all your muscle or nerve conditions, such as ALS or Lou Gehrig’s disease, myasthenia gravis, or Lambert-Eaton syndrome, as you may be at increased risk of serious side effects including difficulty swallowing and difficulty breathing from typical doses of BOTOX® Cosmetic.

Tell your doctor about all your medical conditions, including: plans to have surgery; had surgery on your face; weakness of forehead muscles: trouble raising your eyebrows; drooping eyelids; any other abnormal facial change; are pregnant or plan to become pregnant (it is not known if BOTOX® Cosmetic can harm your unborn baby); are breast-feeding or plan to (it is not known if BOTOX® Cosmetic passes into breast milk).

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal products. Using BOTOX® Cosmetic with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your doctor that you have received BOTOX® Cosmetic in the past.

Tell your doctor if you have received any other botulinum toxin product in the last 4 months; have received injections of botulinum toxin such as Myobloc®, Dysport®, or Xeomin® in the past (tell your doctor exactly which product you received); have recently received an antibiotic by injection; take muscle relaxants; take an allergy or cold medicine; take a sleep medicine; take aspirin-like products or blood thinners.

Other side effects of BOTOX® Cosmetic include: discomfort or pain at the injection site; headache; and eye problems: double vision, blurred vision, drooping eyelids, and swelling of your eyelids.

For more information refer to the Medication Guide or talk with your doctor.

To report a side effect, please call Allergan at 1-800-433-8871.

Please see BOTOX® Cosmetic full Product Information including Boxed Warning and Medication Guide.