what is BOTOX ® Cosmetic?
  • BOTOX® Cosmetic is the only approved treatment to temporarily improve the appearance of both moderate to severe frown lines between the brows and crow’s feet lines in adults.

  • A well-studied treatment
    BOTOX® Cosmetic is one of the most extensively studied medical aesthetic treatments and is approved for cosmetic use in 78 countries.* BOTOX® Cosmetic has a record of experience that aesthetic providers know and trust. And, the safety and efficacy of BOTOX® Cosmetic have been evaluated in both Allergan sponsored clinical trials as well as in 417 peer-reviewed articles in scientific and medical journals.

    *VISTABEL® outside of North America.

  • Derived from sources that exist in nature
    BOTOX® Cosmetic contains tiny amounts of a highly purified botulinum toxin protein refined from the bacterium, Clostridium botulinum. Formulations, potency, and approved doses vary among botulinum toxin products, which means that one product cannot take the place of another. Those are a few reasons why there is no such thing as a “generic” form of BOTOX® Cosmetic. There have been no studies to support that other products are Unit-to-Unit equivalent to BOTOX® Cosmetic.

  • A treatment experienced by millions of people
    Approximately 10.9 million vials of BOTOX® Cosmetic have been sold in the United States since 2002, and millions of people have already made BOTOX® Cosmetic a part of what they do for themselves. Today, BOTOX® Cosmetic is the #1 selling product of its kind in the world.

    Data collected through June 2014.

Actual BOTOX(R) Cosmetic (onabotulinumtoxinA) patient after treatment.
how does BOTOX ® Cosmetic work?
  • BOTOX® Cosmetic targets one of the underlying causes of frown lines and crow’s feet—the repeated muscle contractions from frowning and squinting over the years. Your provider will inject these muscles with BOTOX® Cosmetic to temporarily reduce muscle activity. You will begin to notice a visible smoothing of your crow’s feet lines and frown lines between your brows.

  • Wrinkles result from a combination of many factors. It’s not just about cellular changes that can occur over time, reduction of collagen, or damage caused by free radicals in the sun and the environment. When you frown or concentrate, the muscles between your brows contract, causing your skin to furrow and fold. And when you squint, the muscles around your eyes contract and cause crow’s feet.

    BOTOX® Cosmetic works beneath the skin’s surface and targets the underlying muscle activity that causes frown lines and crow’s feet.

  • For the crow’s feet area, your provider will inject 3 areas of the orbicularis oculi, the muscle that frames the side of the eye. This will be repeated on the orbicularis oculi muscle on the other eye.

    Injecting BOTOX® Cosmetic into the muscles that cause crow’s feet lines temporarily reduces the activity of those muscles. The result is a reduction in the appearance of those lines.

  • For the frown lines area, your provider will administer 5 injections into muscles in your forehead—1 in the procerus muscle and 4 in the corrugator muscles.

    Injecting BOTOX® Cosmetic into the muscles that cause frown lines temporarily reduces the activity of those muscles. The result is a reduction in the appearance of those lines.

Actual BOTOX(R) Cosmetic (onabotulinumtoxinA) patients after treatment. Crow's feet injection points Frown lines injection points
What should I expect with treatment?
  • Real, noticeable results
    You may begin to notice results within 24 to 48 hours for moderate to severe frown lines, with results lasting up to 4 months.

  • Some patients report that being injected with BOTOX® Cosmetic feels like a pinch
    Your provider may use ice to numb the treatment area. If you are concerned about discomfort, your provider may apply a topical numbing cream before administering your treatment.

  • The actual injection process takes about 10 minutes
    Your provider will discuss your treatment goals and perform a facial analysis to determine the appropriate treatment areas for you.

  • You’ll look like yourself—only with less noticeable frown lines and crow’s feet
    BOTOX® Cosmetic is a technique-sensitive treatment. You should not lose the ability to show expression when you are treated by someone who is licensed, trained, and a medical expert in facial anatomy.

  • Return to your daily routine
    Treatment requires minimal downtime or recovery; it’s often called a lunchtime procedure. You’ll be able to go about your normal routine immediately after you leave your provider’s office.

  • Cost considerations
    Your cost not only includes the price of the product, but more importantly, the skill and expertise of the doctor or healthcare professional who is administering your treatment.
    BOTOX® Cosmetic is a technique-sensitive treatment—look for someone who is licensed and trained and has experience treating patients with BOTOX® Cosmetic.

    Be wary of discount products or “cheap” BOTOX® Cosmetic—if it sounds too good to be true, it probably is.

    It is more important to find an experienced provider who will take the time to understand your treatment goals and develop a treatment plan that is right for you.

Before
After (Day 7)

Actual patient. Results may vary.

Photos taken at maximum frown and/or full smile before and after treatment with BOTOX® Cosmetic at day 7. In two clinical studies for moderate to severe crow’s feet, 26.1% and 20.3% of people had ≥ 2-grade improvement at day 30. In one of these studies, 67.9% of people had mild or no crow’s feet at day 30 after treatment. In clinical studies for moderate to severe frown lines, physicians assessed 80% of people had significant improvement at day 30.

Side effects associated with the injection include localized pain, infection, inflammation, tenderness, swelling, redness, and/or bleeding/bruising.

see more photos

Make sure you’re
getting authentic
BOTOX ® Cosmetic
Watch this video to learn how to spot real BOTOX® Cosmetic.
steps you can take
Simple steps to make sure that you are receiving real BOTOX® Cosmetic.
  • Step 1
    See a reputable provider who purchases BOTOX® Cosmetic directly from Allergan or a distributor authorized by Allergan.

    Physicians who purchase BOTOX® Cosmetic from Allergan are listed in the Find a Doctor directory on this website.

  • Step 2
    Ask to see the vial of BOTOX® Cosmetic that the provider will use during your treatment. The vial will have the BOTOX® Cosmetic logo and also have a holographic image that says Allergan.

  • Guaranteed for quality
    When a US provider purchases BOTOX® Cosmetic through Allergan or a distributor authorized by Allergan, it is guaranteed for quality. BOTOX® Cosmetic is a biologic product and follows strict manufacturing, storage, and transportation procedures that prevent it from being compromised.

Authentic BOTOX(R) Cosmetic (onabotulinumtoxinA) vials

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  • Problems swallowing, speaking, or breathing, due to weakening of associated muscles, can be severe and result in loss of life. You are at the highest risk if these problems are pre-existing before injection. Swallowing problems may last for several months
  • Spread of toxin effects. The effect of botulinum toxin may affect areas away from the injection site and cause serious symptoms including: loss of strength and all-over muscle weakness, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing. If this happens, do not drive a car, operate machinery, or do other dangerous activities

The dose of BOTOX® Cosmetic is not the same as, or comparable to, any other botulinum toxin product.

There has not been a confirmed serious case of spread of toxin effect when BOTOX® Cosmetic has been used at the recommended dose to treat frown lines, crow’s feet lines, or both at the same time.

Serious and/or immediate allergic reactions have been reported. They include: itching, rash, red itchy welts, wheezing, asthma symptoms, or dizziness or feeling faint. Tell your doctor or get medical help right away if you are wheezing or have asthma symptoms, or if you become dizzy or faint.

Do not take BOTOX® Cosmetic if you: are allergic to any of the ingredients in BOTOX® Cosmetic (see Medication Guide for ingredients); had an allergic reaction to any other botulinum toxin product such as Myobloc® (rimabotulinumtoxinB), Dysport® (abobotulinumtoxinA), or Xeomin® (incobotulinumtoxinA); have a skin infection at the planned injection site.

Tell your doctor about all your muscle or nerve conditions, such as amyotrophic lateral sclerosis (ALS or Lou Gehrig’s disease), myasthenia gravis, or Lambert-Eaton syndrome, as you may be at increased risk of serious side effects including difficulty swallowing and difficulty breathing from typical doses of BOTOX® Cosmetic.

Tell your doctor about all your medical conditions, including: plans to have surgery; had surgery on your face; weakness of forehead muscles, such as trouble raising your eyebrows; drooping eyelids; any other abnormal facial change; are pregnant or plan to become pregnant (it is not known if BOTOX® Cosmetic can harm your unborn baby); are breast-feeding or plan to breast-feed (it is not known if BOTOX® Cosmetic passes into breast milk).

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal products. Using BOTOX® Cosmetic with certain other medicines may cause serious side effects. Do not start any new medicines until you have told your doctor that you have received BOTOX® Cosmetic in the past.

Especially tell your doctor if you: have received any other botulinum toxin product in the last 4 months; have received injections of botulinum toxin, such as Myobloc®, Dysport®, or Xeomin® in the past (be sure your doctor knows exactly which product you received); have recently received an antibiotic by injection; take muscle relaxants; take an allergy or cold medicine; take a sleep medicine; take aspirin-like products or blood thinners.

Other side effects of BOTOX® Cosmetic include: dry mouth, discomfort or pain at the injection site, tiredness, headache, neck pain, and eye problems: double vision, blurred vision, decreased eyesight, drooping eyelids, swelling of your eyelids, and dry eyes.

For more information refer to the Medication Guide or talk with your doctor.

To report a side effect, please call Allergan at 1-800-433-8871.

Please see BOTOX® Cosmetic full Product Information including Boxed Warning and Medication Guide.

JUVÉDERM® XC AND JUVÉDERM VOLUMA® XC Important Information

Approved Uses
JUVÉDERM® XC injectable gel is for injection into areas of facial tissue where moderate to severe facial wrinkles and folds occur to temporarily add volume to the skin, especially around the nose and mouth.

JUVÉDERM VOLUMA® XC injectable gel is for deep injection in the cheek area to correct age-related volume loss in adults over the age of 21.

Important Safety Information

Are there any reasons why I should not receive JUVÉDERM® XC or JUVÉDERM VOLUMA® XC?
Do not use these products if you have a history of multiple severe allergies or severe allergic reactions (anaphylaxis), or if you are allergic to the proteins (gram-positive bacterial proteins) used to make the hyaluronic acid (HA) in these products. Do not use JUVÉDERM® XC or JUVÉDERM VOLUMA® XC if you are allergic to lidocaine.

What precautions should my healthcare professional advise me about?
  • The safety of JUVÉDERM® XC and JUVÉDERM VOLUMA® XC injectable gels for use during pregnancy or in women who are breastfeeding has not been studied
  • The safety of JUVÉDERM® XC for use in patients under 18 years and JUVÉDERM VOLUMA® XC for patients under 35 years or over 65 years has not been studied
  • The safety and effectiveness of JUVÉDERM® XC for treatment of areas other than facial wrinkles and folds (such as lips) have not been established in clinical studies
  • The safety and effectiveness of JUVÉDERM VOLUMA® XC for treatment in areas other than the cheek area have not been established in clinical studies
  • The safety of JUVÉDERM® XC and JUVÉDERM VOLUMA® XC in patients with a history of excessive scarring (eg, hypertrophic scarring and keloid formations) and pigmentation disorders has not been studied, and use may result in additional scars or changes in pigmentation
  • The safety of JUVÉDERM VOLUMA® XC in patients with very thin skin in the cheek area and the safety of repeat treatments in patients has not been studied
  • There is a possible risk of inflammation at the treatment site if laser procedures and chemical peeling are performed after treatment
  • Patients who experience skin injury near the site of injection with these products may be at a higher risk for side effects
  • Tell your healthcare professional if you are on therapy used to decrease the body’s immune response (immunosuppressive therapy). Use of these products may result in an increased risk of infection
  • Tell your healthcare professional if you are using medications that can prolong bleeding, such as aspirin, ibuprofen, or other blood thinners, as this may result in increased bruising or bleeding at the injection site
  • Minimize strenuous exercise and exposure to extensive sun or heat within the first 24 hours following treatment with JUVÉDERM VOLUMA® XC

What are possible side effects?
For JUVÉDERM® XC, most side effects are mild or moderate in nature, and last 7 days or less. The most common side effects include temporary injection-site reactions such as: redness, pain/tenderness, firmness, swelling, lumps/bumps, bruising, itching, and discoloration.

For JUVÉDERM VOLUMA® XC, side effects are moderate (uncomfortable), and generally last 2 to 4 weeks. The most common side effects include temporary reactions at the treatment site such as tenderness, swelling, firmness, lumps/bumps, bruising, pain, redness, discoloration, and itching.

As with all skin-injection procedures, there is a risk of infection.

To report a side effect with JUVÉDERM® XC or JUVÉDERM VOLUMA® XC, please call Allergan Product Surveillance at 1-800-624-4261.

For more information, please see www.juvederm.com or call the Allergan Medical Information line at 1-800-433-8871.

JUVÉDERM® XC and JUVÉDERM VOLUMA® XC injectable gels are available by prescription only.